NORMAL BLOOD WORK BUT TCEL LYMPHOMA SKIN

NORMAL BLOOD WORK BUT TCEL LYMPHOMA SKIN

If diagnosed early, CTCL can be managed by conventional treatments such as skin-directed therapies (topical steroids, chlormethine gel, phototherapy and local radiotherapy) or systemic therapies (interferon, extracorporeal photopheresis, retinoids, methotrexate, total skin radiotherapy, chemotherapy and allogeneic hematopoietic stem cell transplantation), but they often have short-lived success in patients with advanced-stage disease and, in turn, infections may contribute to the worsening of disease ( 1).

Due to a lack of standardized treatments for all variants of this group of diseases and the indolent nature of early stages, CTCL carries a poor prognosis. Looking forward, we propose strategies to develop more powerful dual CARs that are advancing towards the clinic in CTCL therapy.Ĭutaneous T cell lymphoma (CTCL) is a heterogeneous group of T cell-derived non-Hodgkin lymphomas that affects the skin. In this review, we discuss the current obstacles to CAR-T cell therapy and highlight potential targets in treating CTCL.

To address these critical challenges, innovative CAR engineering by targeting multiple antigens to strike a balance between efficacy and safety of the therapy is necessary. Barriers to effective CAR-T cell therapy in treating CTCL include T cell aplasia in autologous transplants, CAR-T product contamination with leukemic T cells, CAR-T fratricide (when the target antigen is present on normal T cells), and tumor heterogeneity. 4The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, AustraliaĬhimeric antigen receptor (CAR)-T therapy has demonstrated remarkable outcomes for B cell malignancies, however, its application for T cell lymphoma, particularly cutaneous T cell lymphoma (CTCL), has been limited.3Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia.2Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia.1Cartherics Pty Ltd, Notting Hill, VIC, Australia.Evtimov 1, Graham Jenkin 1,2,4, Aleta Pupovac 1, Alan O.

Normal blood work but tcel lymphoma